Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein
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چکیده
منابع مشابه
Crystal Structure of the Bcl-XL-Beclin 1 Peptide Complex
Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressorBeclin 1has beenproposed to coordinate both apoptosis and autophagy through direct interaction with anti-apoptotic family members Bcl-2 and/or Bcl-XL. However, the molecular basis for this interaction remains enigmatic. Herewe report that Beclin 1 contains a conserved BH...
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ژورنال
عنوان ژورنال: Cell Research
سال: 2012
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2012.24